September 23

Amjevita approved by FDA for multiple inflammatory diseases.

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The U.S. Food and Drug Administration today approved Amjevita (adalimumab-atto) as a biosimilar to Abbvie product Humira (adalimumab) for multiple inflammatory diseases.

Enbrel and Humira belong to a class of drugs that treating inflammation by blocking a protein known as tumor necrosis factor.

Manufactured by Amgen.

Amjevita is approved for the treatment of :

  • moderately to severely active rheumatoid arthritis.
  • active psoriatic arthritis.
  • active ankylosing spondylitis (an arthritis that affects the spine).
  • moderately to severely active Crohn’s disease.
  • moderately to severely active ulcerative colitis.
  • moderate to severe plaque psoriasis.

The most serious known adverse events with Amjevita are infections and malignancies. The most common expected adverse reactions with Amjevita are infections and injection site reactions.

Press release from FDA:

http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm522243.htm

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September 23

Zika Virus – Questions & Answers

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What does Zika mean ?

Zika means “overgrown” in the uganda language.

Is Zika new virus ?

No! It is not. Zika virus has discovered long time ago.

When was the last outbreaks of Zike virus ?

Mid 2015 and through 2016.

Where is the last largest outbreak of Zika virus?

Brazil.

How does the Zika virus transmitted?

  • Mosquito bites
  • From a pregnant woman to her fetus
  • Sex
  • Blood transfusion (Not yet confirmed).

What is the name of this Mosquito ?

Aedes mosquito, it also transmits chikungunya, dengue and yellow fever diseases.

Can the Aedes mosquito travel from country to country or region to region?

According to WHO,

The Aedes mosquito is a weak flyer; it cannot fly more than 400 meters. However it may be possible for the mosquito to be transported from one place to another accidentally and introduce Zika virus to new areas.

What are the symptoms of Zika virus ?

common symptoms of Zika are

  • Fever
  • Rash
  • Joint pain
  • Conjunctivitis (red eyes)

Other symptoms include:

  • Muscle pain
  • Headache

Symptoms last for several days to a week. People usually don’t get serious illness to go to the hospital. Once a person has been infected with Zika, they are likely to be protected from future infections.

Why Zika virus infections are serious for some people?

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September 23

List of abused and addicted drugs

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Of course whenever we think about drugs of abuse and addiction, some members of the following list came to our mind:

Disclaimer : Information and names listed below are for educational & scientific purposes only.

Warning : Abusing drugs KILLS!

   1. HEROIN

Heroin is synthesized from morphine in a relatively simple process. Heroin was used instead of codeine and morphine for patients suffering from lung diseases such as tuberculosis. Heroin could be synthesized through the acetylation of morphine in a 10 step process to bring the final product.

Phartoonz

  2. COCAINE

“Smoking crack” and “snorting coke” are the widely used terms that describe the use of Cocaine. It is an alkaloid the present in Coca leaf.  The method of extracting cocaine from coca leaves doesn’t require experts to do it. It is like 1) Extractions 2) Purification & 3) Converting the base to salt in HCL format.

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September 22

PCSK9 Inhibitors – the new injectable cholesterol-lowering drugs

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When statins are not enough to control your body cholesterol levels, adding PCSK9 Inhibitors may help you to lower your bad cholesterol dramatically!

Before inhibiting this enzyme, What does it do ?

Liver removes your bad Cholesterol known as LDL (low denisity lipoproteins). Liver catches this LDL cholesterol through a receptors, PCSK9 as en enzyme binds to those receptors on liver and prevent the liver from doing its good job! so we have to use the PCSK9 Inhibitors to allow the receptor to work properly and lower your bad cholesterol.

PCSK9 Inhibitors VS Statins

Statins have been recognized on the previous 20 years as the gold standard for the treatment of hyperlipidemia so patients who are intolerant to statins may go for PCSK9 inhibitors or use both of them in a combined therapy synergy.

Mechanism of Action :

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September 22

Pfizer – the house of Anti-Infective drugs

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Probably you know about one of the latest acquisitions of the giant US based company Pfizer Inc. Pfizer has acquired small molecules business of Astrazeneca’s anti-infectives.

New products to be added to Pfizer Anti-Infective portfolio:

  • Zinforo(ceftaroline fosamil).
  • Zavicefta (CAZ-AVI).
  • Merrem/Meronem(meropenem).
  • ATM-AVI.
  • CXL.

In addition to the current Pfizer Anti-Infective found in this video :

Source :

http://www.pfizer.com/news/press-release/press-release-detail/pfizer_to_acquire_small_molecule_anti_infective_business_from_astrazeneca

screen-shot-2016-09-23-at-2-02-40-am

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September 21

How to prevent mosquito bites – Stopping Zika transmission

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Up to date there is no vaccine announced to prevent Zika. So that the best way is prevention other than cure! that is through protecting yourself and your family from mosquito bites.
Zika infection during pregnancy can cause fetuses to have a birth defect of the brain damage
called microcephaly. The Zika outbreak has started first time in Brazil.
microcephaly
So preventing mosquito bites is the key to prevent the outbreak and stop transmitting Zika (Zyka) virus,
Many tips have been released by CDC,

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