General Pharmacology Quiz – Medium

1. Isoproterenol produces maximal contraction of cardiac muscle in a manner similar to epinephrine. Which of the following best describes isoproterenol?

2. Two drugs may act on the same tissue or organ through independent receptors, resulting in effects in opposite directions. This is known as

3. In the presence of naloxone, a higher concentration of morphine is required to elicit full pain relief. Naloxone by itself has no effect. Which of the following is correct regarding these medications?

4. Patients with glaucoma were treated with pilocarpine, a unique method of providing round-the-clock delivery of pilocarpine for seven-day periods. This method called?

5. We administer a highly lipid-soluble drug and monitor its elimination in vivo and in vitro. All the data indicate that it is transformed to a variety of more polar and oxidized metabolites by a group of heme proteins that activate molecular oxygen to a form that is capable of interacting with organic substrates such as our test drug. What enzyme or enzyme system is most likely involved in the initial metabolism of this drug?

6. Which of the following is unlikely to be associated with oral drug administration of an enteric-coated dosage form?

7. Which of the following types of drugs will have maximum oral bioavailability

8. Which of the following statements most accurately describes a system having spare receptors?

9. In the presence of picrotoxin, diazepam is less efficacious at causing sedation, regardless of the dose. Picrotoxin by itself has no sedative effect even at the highest dose. Which of the following is correct?

10. Which of the following results in a doubling of the Steady state concentration Css of a drug?

11. Of the following, which is unlikely to be associated with the binding of drugs to plasma proteins?

12. Chlorothiazide is a weakly acidic drug with a pKa of 6.5. If administered orally, at which of the following sites of absorption will the drug be able to readily pass through the membrane?

13. In the presence of pentazocine, a higher concentration of morphine is required to elicit full pain relief. Pentazocine by itself has a smaller analgesic effect than does morphine, even at the highest dose. Which of the following is correct regarding these medications?