General Patho-physiology

Different “ATSHOO” = Different Flu !




When you wake up sneezing , coughing, having a headache or muscle pain ..

How do you know whether you are experiencing cold or flu?? … And if it’s flu , could it be Swine or Avian flu?

That’s why it’s important to know the basic differences between common cold and flu types (regular , swine , avian) .

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ATSHOO No. 1 >>> ” common cold ”  ;


Patients usually experience gradual onset of symptoms over several hours .

symptoms usually last for 7-14 days ,

cough may persist a little longer after the worst of the cold is over .


Symptoms :

– Most of the time start first with a sore dry throat  , which usually goes away after a day or two .

– Runny nose followed by congestion along with a cough by the fourth and fifth days .

–  Feeling hot but in general a high temperature will not be present .

– slight fever is possible but not common , Children are more likely to have a fever with a cold than adults .

the presence of High persistent fever may be an indication that the patient has flu rather than a cold .

– Headache and pain above or below the eyes , that’s mainly due to inflammation and congestion of the nasal passages and sinuses ,

the headache is usually worsened by lying down or bending forward .


Complications :

The most common complication of cold is Earache , especially in children .

earache is mainly due to blockage of the Eustachian tube  ” tube which connects between middle ear and nasal cavity  ”  ,

when the Eustachian tube is blocked , the ear can no longer be cleared by swallowing and may feel uncomfortable or deaf

Decongestants and inhalations can be helpful

sometimes the situation worsens and the middle ear becomes filled up with fluid

this is an ideal site for a secondary bacterial infection to settle called AOM ( acute otitis media) which is very very common in children every where !

in this case the ear becomes painful not just blocked .

80% of children can overcome AOM in about 3 days without using antibiotics

Also there is evidence that both paracetamol and ibuprofen can be effective treatments for AOM .


Treatment :

Usually OTC symptomatic relieving Drugs as the following :

decongestants & antihistaminics , mainly for the Nasal symptoms

Echinacea & Guajava preparations , for treating cough

steam inhalations for Nasal congestion and productive cough

analgesics to relieve the sore and pain sensations

Vitamin c , a systematic review found that high doses of vitamin C ( over 1 gm pre day ) makes a reduction of approximately 15% in the duration of colds .

pharmacist should be aware of adverse effects of OTC medicines.

patients should be advised to see their doctor in 10–14 days if the cold has not improved .

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ATSHOO No. 2 : ” Regular flu

Flu symptoms are usually more severe than cold symptoms and come on quickly .


Symptoms :

– Flu often starts with sweats and chills, and High fever 38°C or higher ( 37.5ºC in the Elderly )

– headaches

– joint pain & muscle aches and soreness

– one or more respiratory symptom (cough, sore throat, nasal
congestion or rhinorrhoea)

– it’s common to experience fatigue and feel run down for a week or more .


Complications :

The complications can include acute otitis media (AOM) , bacterial sinusitis,
bacterial pneumonia and less commonly, viral pneumonia and respiratory failure.

Complications are much more likely to occur in the very young, the very old and those who have pre-existing heart or lung disease (chronic bronchitis) .

Warning that complications could be developing is noticed by severe or productive cough, persisting high fever,
pleuritic-type chest pain or delirium .


Treatment :

Most cases of flu usually resolve within 7 days without  treatment with antiviral drugs ( ex : zanamivir , amantadine and rimantadine )

But they should be considered if the patient is at risk for complications ( old , diabetes , history of lung diseases , .. etc )

Patients are advised to avoid crowded places and excessive contact with others as adults are contagious from the day before symptoms start ,until 5 days after the onset of symptoms .

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ATSHOO No. 3 :  ” Avian \ Bird flu ” .. H5N1


No need to freek out if you wake up sneezing in the morning ! , 99.9% it wont be “ATSHOO No 3

( be & 3 make nice music :whistle: … right :wink: ? )

it’s Not common to catch an Avian flu Unless you often get into direct contact with poultery… it’s not transmitted from one human to another “yet !” .

Infected birds shed influenza virus in their saliva, nasal secretions, and feces , Exposure to one of those is considered most likely during feeding , slaughter, defeathering, butchering, and preparation of poultry for cooking.

Also , getting in contact with sick or dead domestic poultry or surfaces contaminated with poultry feces , or consumption of incompletely cooked poultry can transmit the virus .

So , if a patient is suffering from flu symptoms and owns a small flock of chicken & Ducks or something .. ask him how the Birds are doing ?

Symptoms :

Symptoms are similar to (although usually more severe than) other types of flu :

– sudden onset of fever,

– headache,

– extreme tiredness and aching muscles,

– respiratory symptoms such as a sore throat and cough

Avian influenza cannot be detected by symptoms alone, it is usually diagnosed by collecting a swab from the nose or throat during the first few days of illness to be sent for laboratory tests ( ex: PCR ) .


Complications :

1) Development severe illness and if not treated could lead eventually to death .

2) the risk that the virus – if given enough opportunities – will change into a form that is highly infectious for humans and spreads easily from person to person .


Treatment :

Most H5N1 viruses (which cause Avian flu ) appear to be resistant to amantadine and rimantadine, .

Other antiviral medications as oseltamivir (commercially known as Tamiflu ) and zanamivir (commercialu known as Relenza ) , would probably work good , but additional studies are needed to demonstrate their current and on going effectiveness.


Prevention :

– Wash your hands with soap and warm water for at least 20 seconds before and after handling raw poultry and eggs.
– While Cooking poultrey , make sure you Clean Knives and other cooking utensils with soap and hot water after using them to prevent contaminating other foods.
– make sure you cook poultry to a temperature of at least 74ºC ( 165ºF ).
– Cook eggs until whites and yolks are firm.

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ATSHOO No. 4 :  ” Swine flu ” .. H1N1


This is an influenza virus that had never been identified as a cause of infections in people before the current H1N1 pandemic

H1N1 virus is spread from person to person, similar to seasonal influenza viruses. It is transmitted as easily as the normal seasonal flu and can be passed to other people by exposure to infected droplets expelled by coughing or sneezing that can be inhaled, or that can contaminate hands or surfaces.

But , it is not transmitted by eating pork as long as it’s cooked properly .


Symptoms :

Signs of the swine flu are very similar to the regular one , including :

– High fever ( more than 38ºC )

– headache

– muscle and joint pain

– cough , sore throat and runny nose,

–  vomiting and diarrhoea are seen in many cases .

However ,The majority of Patients experience mild illness and recover fully without any kind of treatment.


complications :

Aggrevation  and worsening of symptoms  , This usually leads to a severe illness as pneumonia and
respiratory failure and eventually death .

some groups of people appear to be at higher risk of more complicated or severe illness, including:

pregnant women , infants, and young children particularly under age 2 ,

people of any age with certain chronic health conditions ( asthma or lung disease , heart disease , diabetes , kidney disease or some neurological conditions ) , people with severely compromised immune systems.

People should seek medical care if they experience shortness of breath or difficulty breathing, or if a fever, and especially high fever, continues more than three days.

For parents with a young child who is ill, seek medical care if a child has fast or labored breathing, continuing fever or convulsions .


Treatment :

– Supportive care at home , resting , drinking plenty of fluids and using a pain reliever for aches and pains  is adequate for recovery in most cases.

– A non-aspirin pain reliever should be used for children or adolescents under age 18.

–  patients who are at increased risk of developing complications or with severe illness and worsening symptoms should get an early treatment with Early treatment with antiviral drugs ( oseltamivir ” Tamiflu ” or zanamivir ” Relenza” ) .


Prevention :

– people who are ill should cover their mouth and nose when coughing or sneezing and stay home as much as possible until they are fully recovered and healthy again .

– avoid the unnecessary touching of the eyes , nose and mouth .

– good cleaning of the hands regularly with soap and water and personal hygiene are very important too .

– pork (pig meat) and other products derived from pigs should be cooked at temperature of atleast 70°C ( 160°F ) to insure complete killing of the virus .




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References :

– text book : Symptoms in Pharmacy , fifth edition

– World Health Organization “WHO” official web site

– Centers for Disease Control “CDC” official web site

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Phartoonz
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Nice tut! :happy:

Amira
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:) wow!! big like

Mahmoud
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thannks 4 the information …..its in time…am im sneezing all the time 4 my firdt day of sneezing but there’s no rise in temp. ,but runny nose with slight feeling hot …so affter this topic i can see i suffer from cold…… thank you again :smile:

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