Drug facts

Mode of Action for Antibiotic Classes – Quick tips

Knowing how do Antibiotics work and fight the infection is an important step for treatment. Resistance is emerging rapidly to most classes and we have to control the use of Antibiotics and avoid misuse or overuse in both community and healthcare society.

Developing Antibiotics resistance has many unfavorable outcomes:

  • Increase the rates of mortality and morbidity.
  • More intervention in terms of surgical or other medical procedures to control the infection.
  • Longer hospital stay or treatment duration and therefor higher costs.
  • Higher costs.
  • Losing the antibiotic makes the treatment options very low and many physicians might feel desperate for selecting an effective antibiotics for complicated cases.

So for different classes of Antibiotics, a quick tips for how they work in terms of mode of action:

The most common antibiotic classes and their mode of action:

Antibiotic Class Example  Mode of Action

Aminoglycosides

Streptomycin

Inhibit protein synthesis

Cephalosporins

Ceftazidime

Inhibit cell wall synthesis

Chloramphenicol

Inhibit protein synthesis

Glycopeptides

Vancomycin

Inhibit cell wall synthesis

Lincosamides

Clindamycin

Inhibit protein synthesis

Macrolides

Erythromycin

Inhibit protein synthesis

Penicillins

Ampicillin

Inhibit cell wall synthesis

Oxazolidinones

Linezolid

Inhibit protein synthesis

Streptogramins

Synercid

Inhibit protein synthesis

Quinolones

Ciprofloxacin

Inhibit  DNA  synthesis

Sulfonamides

Sulfamethoxazole

Inhibit Folic Acid synthesis

Tetracyclines

Doxycycline

Inhibit protein synthesis

Rifamycins

Rifampin

Inhibit  RNA  synthesis

 

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