Paracetamol as Antipyretic

Paracetamol (acetaminophenol) is the most famous Antipyretic on earth

it’s much more safe than aspirin ,

used for Children , Pregnant women , Patients with hyper-acidity Or using anticogulants

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N.B :

Recommended daily dose : 2000 mgs

Not TONS !! ,.. tons are just for dragons !!

in fact,  Large doses cause  Nausea , Vomiting , Diarrhea

& also it causes severe hepato-toxicity + central lobular necrosis

Due to the formation of toxic metabolite “NAPQI”

Hint : Ingestion of 15 gms of paracetamol could be fatal

What is the Antidote of Paracetamol Toxicity?

It is N–Acetyl Cysteine (Nac)

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Reference : ” Basic and Clinical Pharmacology ”  \\ chapter 35 \\ page 444