Benzodiazepines in Liver Failure
By Phartoonz
Key takeaways
Benzodiazepines in liver failure: how the class acts on GABA-A receptors, plus the LOT mnemonic (lorazepam, oxazepam, temazepam) for use in liver disease.
Mechanism of Action of Benzodiazepines:
Benzodiazepines exhibit an affinity for benzodiazepine receptors that act as specific binding sites for gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the CNS. Benzodiazepines are believed to produce their CNS effects by interacting with a macromolecular protein complex in the neuronal membrane that includes GABAA receptors, high-affinity benzodiazepine receptors and chloride channels.
NOT all of this class member are safe in liver disease, however a LOT can be used in patients with liver disease:
LOT
L – Lorazepam
O – Oxazepam
T – Temazepam
All three drugs are not metabolized via the hepatic route.
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